Brusaferri, L;
Bousse, A;
Emond, EC;
Brown, R;
Tsai, Y-J;
Atkinson, D;
Ourselin, S;
... Thielemans, K; + view all
(2020)
Joint Activity and Attenuation Reconstruction from Multiple Energy Window Data with Photopeak Scatter Re-Estimation in non-TOF 3D PET.
IEEE Transactions on Radiation and Plasma Medical Sciences
10.1109/trpms.2020.2978449.
(In press).
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Abstract
Estimation of attenuation from PET data only is of interest for PET-MR and systems where CT is not available or recommended. However, when using data from a single energy window, emission-based non-TOF PET AC methods suffer from ‘cross-talk’ artefacts. Based on earlier work, this manuscript explores the hypothesis that cross-talk can be reduced by using more than one energy window. We propose an algorithm for the simultaneous estimation of both activity and attenuation images as well as the scatter component of the measured data from a PET acquisition, using multiple energy windows. The model for the measurements is 3D and accounts for the finite energy resolution of PET detectors; it is restricted to single scatter. The proposed MLAA-EB-S algorithm is compared with simultaneous estimation from a single energy window (MLAA-S). The evaluation is based on simulations using the characteristics of the Siemens mMR scanner. Phantoms of different complexity were investigated. In particular, a 3D XCAT torso phantom was used to assess the inpainting of attenuation values within the lung region. Results show that the cross-talk present in non-TOF MLAA reconstructions is significantly reduced when using multiple energy windows and indicate that the proposed approach warrants further investigation.
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