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Intrinsically disordered nuclear pore proteins show ideal-polymer morphologies and dynamics

Davis, LK; Ford, IJ; Šarić, A; Hoogenboom, BW; (2020) Intrinsically disordered nuclear pore proteins show ideal-polymer morphologies and dynamics. Physical Review E , 101 (2) , Article 022420. 10.1103/physreve.101.022420. Green open access

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Abstract

In the nuclear pore complex, intrinsically disordered nuclear pore proteins (FG Nups) form a selective barrier for transport into and out of the cell nucleus, in a way that remains poorly understood. The collective FG Nup behavior has long been conceptualized either as a polymer brush, dominated by entropic and excluded-volume (repulsive) interactions, or as a hydrogel, dominated by cohesive (attractive) interactions between FG Nups. Here we compare mesoscale computational simulations with a wide range of experimental data to demonstrate that FG Nups are at the crossover point between these two regimes. Specifically, we find that repulsive and attractive interactions are balanced, resulting in morphologies and dynamics that are close to those of ideal polymer chains. We demonstrate that this property of FG Nups yields sufficient cohesion to seal the transport barrier, and yet maintains fast dynamics at the molecular scale, permitting the rapid polymer rearrangements needed for transport events.

Type: Article
Title: Intrinsically disordered nuclear pore proteins show ideal-polymer morphologies and dynamics
Open access status: An open access version is available from UCL Discovery
DOI: 10.1103/physreve.101.022420
Publisher version: https://doi.org/10.1103/physreve.101.022420
Language: English
Additional information: This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Physics and Astronomy
URI: https://discovery.ucl.ac.uk/id/eprint/10093017
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