Philip, KEJ;
Sadaka, AS;
Polkey, MI;
Hopkinson, NS;
Steptoe, A;
Fancourt, D;
(2020)
The prevalence and associated mortality of non‐anaemic iron deficiency in older adults: a 14 years observational cohort study.
British Journal of Haematology
, 189
(3)
pp. 566-572.
10.1111/bjh.16409.
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Abstract
Iron is central to multiple biological pathways, and treatment of non-anaemic absolute iron deficiency (NAID) is beneficial in certain conditions. However, it is unknown if NAID is associated with increased mortality in older adults. A nationally representative sample of 4451 older adults from the English Longitudinal Study of Ageing was used. NAID was defined as serum ferritin < 30 μg/l and haemoglobin ≥ 120 g/l (women) or ≥ 130 g/l (men). Cumulative mortality was estimated by Kaplan-Meier method. Unadjusted and adjusted hazard ratios (HRs) of mortality were calculated using Cox proportional hazards regression models. Baseline NAID prevalence was 8·8% (95% confidence interval [CI] 8·0-9·7%); 10·9% (95% CI 9·7-12·3%) for women and 6·35% for men (95% CI 5·3-7·5%). The HR for mortality for individuals with NAID compared with non-anaemic individuals without iron deficiency over the 14-year follow-up was 1·58 (95% CI 1·29-1·93). This association was independent of all identified demographic, health-related and biological covariates, and robust in multiple sensitivity analyses. In older adults in England, NAID is common and associated with an increased mortality rate compared to non-anaemic individuals with normal serum ferritin. The association is principally driven by an excess mortality in women.
Type: | Article |
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Title: | The prevalence and associated mortality of non‐anaemic iron deficiency in older adults: a 14 years observational cohort study |
Location: | England |
Open access status: | An open access version is available from UCL Discovery |
DOI: | 10.1111/bjh.16409 |
Publisher version: | http://dx.doi.org/10.1111/bjh.16409 |
Language: | English |
Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
Keywords: | iron deficiency, mortality, non-anaemic, older adults |
UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Behavioural Science and Health |
URI: | https://discovery.ucl.ac.uk/id/eprint/10092906 |
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