UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

The prevalence and associated mortality of non‐anaemic iron deficiency in older adults: a 14 years observational cohort study

Philip, KEJ; Sadaka, AS; Polkey, MI; Hopkinson, NS; Steptoe, A; Fancourt, D; (2020) The prevalence and associated mortality of non‐anaemic iron deficiency in older adults: a 14 years observational cohort study. British Journal of Haematology , 189 (3) pp. 566-572. 10.1111/bjh.16409. Green open access

[thumbnail of Francourt_NAID and Mortality BJH accepted.pdf]
Preview
Text
Francourt_NAID and Mortality BJH accepted.pdf - Accepted Version

Download (679kB) | Preview

Abstract

Iron is central to multiple biological pathways, and treatment of non-anaemic absolute iron deficiency (NAID) is beneficial in certain conditions. However, it is unknown if NAID is associated with increased mortality in older adults. A nationally representative sample of 4451 older adults from the English Longitudinal Study of Ageing was used. NAID was defined as serum ferritin < 30 μg/l and haemoglobin ≥ 120 g/l (women) or ≥ 130 g/l (men). Cumulative mortality was estimated by Kaplan-Meier method. Unadjusted and adjusted hazard ratios (HRs) of mortality were calculated using Cox proportional hazards regression models. Baseline NAID prevalence was 8·8% (95% confidence interval [CI] 8·0-9·7%); 10·9% (95% CI 9·7-12·3%) for women and 6·35% for men (95% CI 5·3-7·5%). The HR for mortality for individuals with NAID compared with non-anaemic individuals without iron deficiency over the 14-year follow-up was 1·58 (95% CI 1·29-1·93). This association was independent of all identified demographic, health-related and biological covariates, and robust in multiple sensitivity analyses. In older adults in England, NAID is common and associated with an increased mortality rate compared to non-anaemic individuals with normal serum ferritin. The association is principally driven by an excess mortality in women.

Type: Article
Title: The prevalence and associated mortality of non‐anaemic iron deficiency in older adults: a 14 years observational cohort study
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/bjh.16409
Publisher version: http://dx.doi.org/10.1111/bjh.16409
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: iron deficiency, mortality, non-anaemic, older adults
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Behavioural Science and Health
URI: https://discovery.ucl.ac.uk/id/eprint/10092906
Downloads since deposit
86Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item