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Radiobiological Implications of Nanoparticles Following Radiation Treatment

Ahmad, R; Schettino, G; Royle, G; Barry, M; Pankhurst, QA; Tillement, O; Russell, B; (2020) Radiobiological Implications of Nanoparticles Following Radiation Treatment. Particle & Particle Systems Characterization , 37 (4) , Article 1900411. 10.1002/ppsc.201900411. Green open access

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Abstract

Materials with a high atomic number (Z) are shown to cause an increase in the level of cell kill by ionizing radiation when introduced into tumor cells. This study uses in vitro experiments to investigate the differences in radiosensitization between two cell lines (MCF‐7 and U87) and three commercially available nanoparticles (gold, gadolinium, and iron oxide) irradiated by 6 MV X‐rays. To assess cell survival, clonogenic assays are carried out for all variables considered, with a concentration of 0.5 mg mL−1 for each nanoparticle material used. This study demonstrates differences in cell survival between nanoparticles and cell line. U87 shows the greatest enhancement with gadolinium nanoparticles (2.02 ± 0.36), whereas MCF‐7 cells have higher enhancement with gold nanoparticles (1.74 ± 0.08). Mass spectrometry, however, shows highest elemental uptake with iron oxide and U87 cells with 4.95 ± 0.82 pg of iron oxide per cell. A complex relationship between cellular elemental uptake is demonstrated, highlighting an inverse correlation with the enhancement, but a positive relation with DNA damage when comparing the same nanoparticle between the two cell lines.

Type: Article
Title: Radiobiological Implications of Nanoparticles Following Radiation Treatment
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/ppsc.201900411
Publisher version: https://doi.org/10.1002/ppsc.201900411
Language: English
Additional information: Copyright © 2020 The Authors. Published by WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim. This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Keywords: cancer therapy, nanoparticle‐enhanced radiotherapy, radiation therapy, radiosensitization
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Targeted Intervention
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/10092902
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