Silva, SL;
Albuquerque, A;
Amaral, AJ;
Li, Q-Z;
Mota, C;
Cheynier, R;
Victorino, RMM;
... Sousa, AE; + view all
(2017)
Autoimmunity and allergy control in adults submitted to complete thymectomy early in infancy.
PLoS One
, 12
(7)
, Article e0180385. 10.1371/journal.pone.0180385.
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Abstract
The contribution of the decline in thymic activity for the emergence of autoimmunity is still debatable. Immune-competent adults submitted to complete thymectomy early in life provide a unique model to address this question. We applied here strict criteria to identify adults lacking thymic activity based on sjTREC levels, to exclude thymic rebound and/or ectopic thymuses. In agreement, they featured severe naïve CD4 T-cell depletion and contraction of T-cell receptor diversity. Notwithstanding this, there was neither increased incidence of autoimmune disease in comparison with age-matched controls nor significant changes in their IgG/IgA/IgM/IgE autoreactivity profiles, as assessed through extensive arrays. We reasoned that the observed relative preservation of the regulatory T-cell compartment, including maintenance of naïve regulatory CD4 T-cells, may contribute to limit the emergence of autoimmunity upon thymectomy. Our findings have implications in other clinical settings with impaired thymic activity, and are particularly relevant to studies of autoimmunity in ageing.
| Type: | Article |
|---|---|
| Title: | Autoimmunity and allergy control in adults submitted to complete thymectomy early in infancy |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1371/journal.pone.0180385 |
| Publisher version: | http://dx.doi.org/10.1371/journal.pone.0180385 |
| Language: | English |
| Additional information: | © 2017 Silva et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| Keywords: | Adult, Aging, Autoimmune Diseases, CD4 Lymphocyte Count, CD4-Positive T-Lymphocytes, Female, Gene Expression, Humans, Hypersensitivity, Immunocompetence, Immunoglobulin Isotypes, Infant, Longitudinal Studies, Male, Receptors, Antigen, T-Cell, T-Lymphocytes, Regulatory, Thymectomy, Thymus Gland |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10092885 |
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