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Tuberculosis Antigen-Specific T-Cell Responses During the First 6 Months of Antiretroviral Treatment

Riou, C; Jhilmeet, N; Rangaka, MX; Wilkinson, RJ; Wilkinson, KA; (2020) Tuberculosis Antigen-Specific T-Cell Responses During the First 6 Months of Antiretroviral Treatment. The Journal of Infectious Diseases , 221 (1) pp. 162-167. 10.1093/infdis/jiz417. Green open access

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Abstract

The reconstitution of Mycobacterium tuberculosis antigen-specific CD4 T cells in a cohort of HIV-infected persons starting antiretroviral treatment (ART) in a high tuberculosis endemic area is described. Restoration of the antigen-specific CD4 T-cell subsets mirrored the overall CD4 T-cell compartment. Activation (assessed by HLA-DR expression) decreased during ART but remained elevated compared to HIV-uninfected persons. Despite known M. tuberculosis sensitization determined by interferon-γ release assay, 12/23 participants had no M. tuberculosis-specific CD4 T cells detectable by flow cytometry, combined with overall elevated T-cell activation and memory differentiation, suggesting heightened turnover. Our data suggest early ART initiation to maintain polyfunctional immune memory responses.

Type: Article
Title: Tuberculosis Antigen-Specific T-Cell Responses During the First 6 Months of Antiretroviral Treatment
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1093/infdis/jiz417
Publisher version: https://doi.org/10.1093/infdis/jiz417
Language: English
Additional information: Copyright © The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: antiretroviral treatment, immune activation, immune reconstitution, protection, tuberculosis
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health
URI: https://discovery.ucl.ac.uk/id/eprint/10092649
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