Maurice, J;
Pinzani, M;
(2020)
The stratification of cirrhosis.
Hepatology Research
, 50
(5)
pp. 535-541.
10.1111/hepr.13493.
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Abstract
Cirrhosis is traditionally seen as an irreversible stage of chronic liver disease although its clinical course may last several years. Overall, the clinical management of cirrhotic patients is based on the observation of clinical events mostly related to complication of portal hypertension. Each event of cirrhosis decompensation has clear prognostic implication although it is not precisely predictable. In practice, the advancement in the knowledge of the mechanisms responsible for disease progression is not yet translated in clinical tools allowing the stratification of the cirrhotic stage according to pathophysiological mechanisms. This article provides a review of the main clinical and histopathogical features of liver cirrhosis that are relevant for its clinical stratification together with the advancements provided by the introduction of non-invasive measures of portal hypertension. Other clinical aspects with a major impact of the quality of life and the possibility of liver transplantation are also discussed.
| Type: | Article |
|---|---|
| Title: | The stratification of cirrhosis |
| Location: | Netherlands |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/hepr.13493 |
| Publisher version: | https://doi.org/10.1111/hepr.13493 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Cirrhosis, elastography, hepatic venous pressure gradient (HVPG), hepatocellular carcinoma (HCC), liver transplantation, sarcopenia |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inst for Liver and Digestive Hlth |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10092531 |
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