Papathanasiou, MM; Stamatis, C; Lakelin, M; Farid, S; Titchener-Hooker, N; Shah, N; (2020) Autologous CAR T-cell therapies supply chain: challenges and opportunities? Cancer Gene Therapy 10.1038/s41417-019-0157-z. (In press).

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Abstract

Chimeric antigen receptor (CAR) T cells are considered a potentially disruptive cancer therapy, showing highly promising results. Their recent success and regulatory approval (both in the USA and Europe) are likely to generate a rapidly increasing demand and a need for the design of robust and scalable manufacturing and distribution models that will ensure timely and cost-effective delivery of the therapy to the patient. However, there are challenging tasks as these therapies are accompanied by a series of constraints and particularities that need to be taken into consideration in the decision-making process. Here, we present an overview of the current state of the art in the CAR T cell market and present novel concepts that can debottleneck key elements of the current supply chain model and, we believe, help this technology achieve its long-term potential.

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