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Autologous CAR T-cell therapies supply chain: challenges and opportunities?

Papathanasiou, MM; Stamatis, C; Lakelin, M; Farid, S; Titchener-Hooker, N; Shah, N; (2020) Autologous CAR T-cell therapies supply chain: challenges and opportunities? Cancer Gene Therapy 10.1038/s41417-019-0157-z. (In press). Green open access

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Abstract

Chimeric antigen receptor (CAR) T cells are considered a potentially disruptive cancer therapy, showing highly promising results. Their recent success and regulatory approval (both in the USA and Europe) are likely to generate a rapidly increasing demand and a need for the design of robust and scalable manufacturing and distribution models that will ensure timely and cost-effective delivery of the therapy to the patient. However, there are challenging tasks as these therapies are accompanied by a series of constraints and particularities that need to be taken into consideration in the decision-making process. Here, we present an overview of the current state of the art in the CAR T cell market and present novel concepts that can debottleneck key elements of the current supply chain model and, we believe, help this technology achieve its long-term potential.

Type: Article
Title: Autologous CAR T-cell therapies supply chain: challenges and opportunities?
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/s41417-019-0157-z
Publisher version: https://doi.org/10.1038/s41417-019-0157-z
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Cancer, Diseases
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Biochemical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/10092522
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