UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Recognising the broad array of approaches available for the diagnosis of ancient tuberculosis: Comment on 'Infectious diseases and Neolithic transformations' (Fuchs et al. 2019 The Holocene 29: 1545-1557)

Minnikin, DE; Lee, OY-C; Wu, HHT; Besra, GS; Donoghue, HD; (2020) Recognising the broad array of approaches available for the diagnosis of ancient tuberculosis: Comment on 'Infectious diseases and Neolithic transformations' (Fuchs et al. 2019 The Holocene 29: 1545-1557). The Holocene 10.1177/0959683619895572. (In press). Green open access

[thumbnail of Minnikin et al 2020.pdf]
Preview
Text
Minnikin et al 2020.pdf - Accepted Version

Download (308kB) | Preview

Abstract

The characterisation of ancient tuberculosis is not totally dependent on the recovery of intact genomes. Judicious combinations of ancient DNA fragments and specific lipid biomarkers provide unambiguous diagnosis and these protocols are capable of refinement and extension. Currently, there is no direct evidence for exclusive co-evolution of humans and tuberculosis. A developing body of data suggests that the initial evolution of tuberculosis may readily have taken place in a range of Pleistocene megafauna.

Type: Article
Title: Recognising the broad array of approaches available for the diagnosis of ancient tuberculosis: Comment on 'Infectious diseases and Neolithic transformations' (Fuchs et al. 2019 The Holocene 29: 1545-1557)
Open access status: An open access version is available from UCL Discovery
DOI: 10.1177/0959683619895572
Publisher version: https://doi.org/10.1177/0959683619895572
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Science & Technology, Physical Sciences, Geography, Physical, Geosciences, Multidisciplinary, Physical Geography, Geology, ancient tuberculosis, DNA fragment amplification, genomes, lipid biomarkers, paleopathology, Pleistocene megafauna, tuberculosis evolution, MYCOBACTERIUM-TUBERCULOSIS, BIOMARKERS, EVOLUTION
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity
URI: https://discovery.ucl.ac.uk/id/eprint/10091998
Downloads since deposit
73Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item