UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Co-registered combined OCT and THz imaging to extract depth and refractive index of a tissue-equivalent test object

Fitzgerald, A; Tie, X; Hackman, M; cense, B; Gibson, A; Wallace, V; (2020) Co-registered combined OCT and THz imaging to extract depth and refractive index of a tissue-equivalent test object. Biomedical Optics Express , 11 (3) pp. 1417-1431. 10.1364/boe.378506. Green open access

[img]
Preview
Text
boe-11-3-1417.pdf - Published version

Download (973kB) | Preview

Abstract

Terahertz (THz) imaging and optical coherence tomography (OCT) provide complementary information with similar length scales. In addition to OCT’s extensive use in ophthalmology, both methods have shown some promise for other medical applications and non-destructive testing. In this paper, we present an iterative algorithm that combines the information from OCT and THz imaging at two different measurement locations within an object to determine both the depth of the reflecting layers at the two locations and the unknown refractive index of the medium for both the OCT wavelengths and THz frequencies. We validate this algorithm using a silicone test object with embedded layers and show that the depths and refractive index values obtained from the algorithm agreed with the measured values to within 3.3%. We further demonstrate for the first time that OCT and THz images can be co-registered and aligned using unsupervised image registration. Hence we show that a combined OCT/THz system can provide unique information beyond the capability of the separate modalities alone, with possible applications in the medical, industrial and pharmaceutical sectors.

Type: Article
Title: Co-registered combined OCT and THz imaging to extract depth and refractive index of a tissue-equivalent test object
Open access status: An open access version is available from UCL Discovery
DOI: 10.1364/boe.378506
Publisher version: https://doi.org/10.1364/boe.378506
Language: English
Additional information: Copyright © 2020 Optical Society of America under the terms of the OSA Open Access Publishing Agreement (https://doi.org/10.1364/OA_License_v1).
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of the Built Environment
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of the Built Environment > Bartlett School Env, Energy and Resources
URI: https://discovery.ucl.ac.uk/id/eprint/10091909
Downloads since deposit
8Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item