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The effect of dopamine on the comprehension of spectrally-shifted noise-vocoded speech: a pilot study

Cardin, V; Rosen, S; Konieczny, L; Coulson, K; Lametti, D; Edwards, M; Woll, B; (2020) The effect of dopamine on the comprehension of spectrally-shifted noise-vocoded speech: a pilot study. International Journal of Audiology 10.1080/14992027.2020.1734675. (In press).

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Abstract

Objectives: Cochlear implantation has proven beneficial in restoring hearing. However, success is variable, and there is a need for a simple post-implantation therapy that could significantly increase implantation success. Dopamine has a general role in learning and in assigning value to environmental stimuli. We tested the effect of dopamine in the comprehension of spectrally-shifted noise-vocoded (SSNV) speech, which simulates, in hearing individuals, the signal delivered by a cochlear implant (CI). Design and study sample: Thirty-five participants (age = 38.0 ± 10.1 SD) recruited from the general population were divided into three groups. We tested SSNV speech comprehension in two experimental sessions. In one session, a metabolic precursor of dopamine (L-DOPA) was administered to participants in two of the groups; a placebo was administered in the other session. Results: A single dose of L-DOPA interacted with training to improve perception of SSNV speech, but did not significantly accelerate learning. Conclusions: These findings are a first step in exploring the use of dopamine to enhance speech understanding in CI patients. Replications of these results using SSNV in individuals with normal hearing, and also in CI users, are needed to determine whether these effects can translate into benefits in everyday language comprehension.

Type: Article
Title: The effect of dopamine on the comprehension of spectrally-shifted noise-vocoded speech: a pilot study
DOI: 10.1080/14992027.2020.1734675
Publisher version: https://doi.org/10.1080/14992027.2020.1734675
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Cochlear implant, pharmacology, speech perception, noise
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Experimental Psychology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Speech, Hearing and Phonetic Sciences
URI: https://discovery.ucl.ac.uk/id/eprint/10091907
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