UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Clinical Germline Genome Editing: When Will Good be Good Enough?

O'Neill, H; (2020) Clinical Germline Genome Editing: When Will Good be Good Enough? Perspectives in Biology and Medicine , 63 (1) pp. 101-110. 10.1353/pbm.2020.0008. Green open access

[thumbnail of O'Neill_Clinical Germline Genome Editing. When Will Good be Good Enough_AAM.pdf]
Preview
Text
O'Neill_Clinical Germline Genome Editing. When Will Good be Good Enough_AAM.pdf - Accepted Version

Download (283kB) | Preview

Abstract

Ensuring experimental outcomes are of the highest clinical caliber is crucial prior to the introduction of germline genome editing. However, if we are to police scientific progress using probability or the potential to go wrong, then we must account for the specious standards of human reproduction. With 15% of clinically recognized pregnancies estimated to end in spontaneous miscarriage within the first trimester, and 25% of all pregnancies ending in miscarriage, human reproduction has a high failure rate. These figures, coupled with the percentage of all births with congenital defects and the number of these who will die in the first year of life, paint two scenarios: one, that evolutionary checkpoints are cruel but critical, and two, that for the seemingly inevitable 3%, or 8 million babies born annually with congenital disorders, perhaps more must be done for prevention, when methods exist for prediction. Unifying progress in three coevolving technologies—assisted reproduction, genome editing, and genome sequencing—could produce revolutionary clinical changes in the harsh global statistics of hereditary disease. A historical perspective on the rocky foundations upon which IVF was built suggests that lessons should be learned from the misalignment of research and clinical practice due to funding and research restrictions. At present, it seems likely that history will repeat itself, and that progress in research will be hampered by hypocritical hesitation.

Type: Article
Title: Clinical Germline Genome Editing: When Will Good be Good Enough?
Open access status: An open access version is available from UCL Discovery
DOI: 10.1353/pbm.2020.0008
Publisher version: https://doi.org/10.1353/pbm.2020.0008
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Reproductive Health
URI: https://discovery.ucl.ac.uk/id/eprint/10091743
Downloads since deposit
106Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item