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Effects of spatial dimensionality and steric interactions on microtubule-motor self-organization

Rickman, J; Nédélec, F; Surrey, T; (2019) Effects of spatial dimensionality and steric interactions on microtubule-motor self-organization. Physical Biology , 16 (4) , Article 046004. 10.1088/1478-3975/ab0fb1. Green open access

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Abstract

Active networks composed of filaments and motor proteins can self-organize into a variety of architectures. Computer simulations in two or three spatial dimensions and including or omitting steric interactions between filaments can be used to model active networks. Here we examine how these modelling choices affect the state space of network self-organization. We compare the networks generated by different models of a system of dynamic microtubules and microtubule-crosslinking motors. We find that a thin 3D model that includes steric interactions between filaments is the most versatile, capturing a variety of network states observed in recent experiments. In contrast, 2D models either with or without steric interactions which prohibit microtubule crossings can produce some, but not all, observed network states. Our results provide guidelines for the most appropriate choice of model for the study of different network types and elucidate mechanisms of active network organization.

Type: Article
Title: Effects of spatial dimensionality and steric interactions on microtubule-motor self-organization
Open access status: An open access version is available from UCL Discovery
DOI: 10.1088/1478-3975/ab0fb1
Publisher version: https://doi.org/10.1088/1478-3975/ab0fb1
Language: English
Additional information: Original content from this work may be used under the terms of the Creative Commons Attribution 3.0 licence (http://creativecommons.org/licenses/by/3.0). Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of the Built Environment
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of the Built Environment > Bartlett School Env, Energy and Resources
URI: https://discovery.ucl.ac.uk/id/eprint/10091663
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