UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Failures in Protein Clearance Partly Underlie Late Onset Neurodegenerative Diseases and Link Pathology to Genetic Risk

Hardy, J; (2019) Failures in Protein Clearance Partly Underlie Late Onset Neurodegenerative Diseases and Link Pathology to Genetic Risk. Frontiers in Neuroscience , 13 , Article 1304. 10.3389/fnins.2019.01304. Green open access

[thumbnail of fnins-13-01304.pdf]
Preview
Text
fnins-13-01304.pdf - Published Version

Download (182kB) | Preview

Abstract

As we identify the loci involved in late onset neurodegenerative disease, we are finding that the majority of them are involved in damage response processes. In this short review, I propose that it is partly a failure in these damage response processes which underlie late onset disease and that the resultant pathology is a marker of the type of damage response which has failed: microglial clearance of damaged neuronal membranes in Alzheimer’s disease (AD), ubiquitin proteasome clearance in the tauopathies, and lysosomal clearance in Parkinson’s disease (PD). In this review, I outline this relationship. This article is not intended as a comprehensive review of the cell biology of any of these disorders but rather a summary of the evidence that the genetics and pathology of these disorders appear to point, in each case, to the removal of misfolded proteins as a critical process in disease pathogenesis.

Type: Article
Title: Failures in Protein Clearance Partly Underlie Late Onset Neurodegenerative Diseases and Link Pathology to Genetic Risk
Open access status: An open access version is available from UCL Discovery
DOI: 10.3389/fnins.2019.01304
Publisher version: https://doi.org/10.3389/fnins.2019.01304
Language: English
Additional information: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Keywords: Science & Technology, Life Sciences & Biomedicine, Neurosciences, Neurosciences & Neurology, Alzheimer's disease, Parkinson's disease, progressive supranuclear palsy, APP, MAPT, SNCA, ALZHEIMERS-DISEASE, ALPHA-SYNUCLEIN, AMYLOID HYPOTHESIS, TAU, ASSOCIATION, MUTATIONS, HAPLOTYPE, VARIANTS
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/10091636
Downloads since deposit
35Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item