Xiao, F;
Koepp, MJ;
Zhou, D;
(2019)
Pharmaco-fMRI: A Tool to Predict the Response to Antiepileptic Drugs in Epilepsy.
Frontiers in Neurology
, 10
, Article 1203. 10.3389/fneur.2019.01203.
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Abstract
Pharmacological treatment with antiepilepticmedications (AEDs) in epilepsy is associated with a variety of neurocognitive side effects. However, the mechanisms underlying these side effects, and why certain brain anatomies are more affected still remain poorly understood. Advanced functional magnetic resonance imaging (fMRI) methods, such as pharmaco-fMRI, can investigate medication-related effects on brain activities using task and resting state fMRI and showing reproducible activation and deactivation patterns. This methodological approach has been used successfully to complement neuropsychological studies of AEDs. Here we review pharmaco-fMRI studies in people with epilepsy targeting the most-widely prescribed AEDs. Pharmco-fMRI has advanced our understanding of the impact of AEDs on specific brain networks and thus may provide potential biomarkers to move beyond the current “trial and error” approach when commencing anti-epileptic medication.
| Type: | Article |
|---|---|
| Title: | Pharmaco-fMRI: A Tool to Predict the Response to Antiepileptic Drugs in Epilepsy |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3389/fneur.2019.01203 |
| Publisher version: | https://doi.org/10.3389/fneur.2019.01203 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Clinical Neurology, Neurosciences, Neurosciences & Neurology, functional MRI, epilepsy, antiepileptic drugs, pharmaco-fMRI, side-effects, drug response, JUVENILE MYOCLONIC EPILEPSY, GRAPH-THEORETICAL ANALYSIS, BENIGN CHILDHOOD EPILEPSY, TEMPORAL-LOBE EPILEPSY, WORKING-MEMORY, CENTROTEMPORAL SPIKES, LANGUAGE DISTURBANCES, COGNITIVE IMPAIRMENT, FUNCTIONAL MRI, BRAIN NETWORKS |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Experimental Epilepsy |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10091614 |
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