Bordoni, V;
Lalle, E;
Colavita, F;
Baiocchini, A;
Nardacci, R;
Falasca, L;
Carletti, F;
... Castilletti, C; + view all
(2019)
Rescue of Replication-Competent ZIKV Hidden in Placenta-Derived Mesenchymal Cells Long After the Resolution of the Infection.
Open Forum Infectious Diseases
, 6
(10)
, Article ofz342. 10.1093/ofid/ofz342.
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Abstract
The Zika virus (ZIKV) genome, its negative-strand viral proteins, and virus-like particles were detected in placenta-derived mesenchymal cells (MSCs), indicating that ZIKV persists after virus clearance from maternal blood and can be rescued by in vitro cultivation. We report for the first time the presence of replication-competent ZIKV in MSCs from an asymptomatic woman who acquired infection during pregnancy.
| Type: | Article |
|---|---|
| Title: | Rescue of Replication-Competent ZIKV Hidden in Placenta-Derived Mesenchymal Cells Long After the Resolution of the Infection |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1093/ofid/ofz342 |
| Publisher version: | https://doi.org/10.1093/ofid/ofz342 |
| Language: | English |
| Additional information: | Copyright © The Author(s) 2019. Published by Oxford University Press on behalf of Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
| Keywords: | Zika virus, vertical transmission, placenta, mesenchymal cells, viral reservoir |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10091596 |
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