Leira, Y;
Carballo, Á;
Orlandi, M;
Aldrey, JM;
Pías-Peleteiro, JM;
Moreno, F;
Vázquez-Vázquez, L;
... Blanco, J; + view all
(2020)
Periodontitis and Systemic Markers of Neurodegeneration. A case-control study.
Journal of Clinical Periodontology
, 47
(5)
pp. 561-571.
10.1111/jcpe.13267.
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Abstract
Aim: To investigate whether periodontitis is associated with amyloid beta (Aβ) peptides and whether systemic inflammation could act as a potential mediator of this link. Materials and Methods: A case–control study was designed including 75 patients with periodontitis (cases) and 75 age‐balanced and gender‐matched participants without periodontitis (controls). Full‐mouth periodontal evaluation was performed in all participants. Demographic, clinical and behaviour data were also recorded. Fasting blood samples were collected, and serum levels of interleukin 6 (IL‐6), high‐sensitivity C‐reactive protein (hs‐CRP), Aβ1‐40 and Aβ1‐42 were determined. Results: Cases showed higher levels of IL‐6 (8.7 ± 3.2 vs. 4.8 ± 0.5 pg/ml), hs‐CRP (3.3 ± 1.2 vs. 0.9 ± 0.7 mg/L), Aβ1‐40 (37.3 ± 6.0 vs. 30.3 ± 1.8 pg/ml) and Aβ1‐42 (54.5 ± 10.6 vs. 36.5 ± 10.0 pg/ml) when compared to controls (all p < .001). Diagnosis of periodontitis was statistically significantly associated with circulating Aβ1‐40 (urn:x-wiley:03036979:media:jcpe13267:jcpe13267-math-0001 = 6.9, 95% CI: 5.4–8.3; p < .001) and Aβ1‐42 (urn:x-wiley:03036979:media:jcpe13267:jcpe13267-math-0002 = 17.8, 95% CI: 14.4–21.3; p < .001). Mediation analysis confirmed hs‐CRP and IL‐6 as mediators of this association. Conclusions: Periodontitis is associated with increased peripheral levels of Aβ. This finding could be explained by enhanced systemic inflammation that can be seen in patients with periodontitis.
| Type: | Article |
|---|---|
| Title: | Periodontitis and Systemic Markers of Neurodegeneration. A case-control study |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/jcpe.13267 |
| Publisher version: | https://doi.org/10.1111/jcpe.13267 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | amyloid beta peptides, C‐reactive protein, neurodegeneration periodontitis, systemic inflammation |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > Restorative Dental Sciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10091512 |
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