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A possible role for sarcosine in the management of schizophrenia

Curtis, D; (2019) A possible role for sarcosine in the management of schizophrenia. The British Journal of Psychiatry , 215 (6) pp. 697-698. 10.1192/bjp.2019.194. Green open access

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Abstract

Sarcosine, which is freely sold as a dietary supplement, has pharmacological activity to boost functioning of the glutamatergic N-methyl-d-aspartate receptor (NMDAR) and hence it is a biologically rational treatment for schizophrenia. The small number of studies carried out to date provide some evidence for its efficacy and psychiatrists could consider suggesting its use to their patients.

Type: Article
Title: A possible role for sarcosine in the management of schizophrenia
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1192/bjp.2019.194
Publisher version: https://doi.org/10.1192/bjp.2019.194
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Sarcosine, glutamate, glycine, pharmacology, schizophrenia
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment
URI: https://discovery.ucl.ac.uk/id/eprint/10091060
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