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Macular Pigment Distribution as Prognostic Marker for Disease Progression in Macular Telangiectasia Type 2

Mueller, S; Issa, PC; Heeren, TFC; Thiele, S; Holz, FG; Herrmann, P; (2018) Macular Pigment Distribution as Prognostic Marker for Disease Progression in Macular Telangiectasia Type 2. American Journal of Ophthalmology , 194 pp. 163-169. 10.1016/j.ajo.2018.07.017. Green open access

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Abstract

PURPOSE To evaluate macular pigment distribution pattern as a prognostic marker for disease progression in patients with macular telangiectasia type 2 (MacTel). DESIGN Retrospective cohort study. METHODS In this single-center study, 90 eyes of 47 patients were analyzed. Macular pigment optical density (MPOD) was measured with dual-wavelength fundus autofluorescence. Eyes were graded into MPOD distribution classes 1 to 3 with increasing loss of macular pigment and grading was performed masked by 2 independent graders. Best-corrected visual acuity, reading acuity, total scotoma size in fundus-controlled perimetry (microperimetry), and break of the ellipsoid zone (EZ) in optical coherence tomography (en face measurement) were defined as functional and morphologic outcome parameters and evaluated at baseline and after 60 months. RESULTS After a mean review period of 59.6 months (±standard deviation 5.2 months), no change between MPOD classes was observed compared to baseline. Morphologic and functional deficits were limited to the area of MPOD loss. At last follow-up, a significant mean decrease of visual acuity and reading acuity as well as a significant mean increase of scotoma size and EZ break were observed in eyes assigned to MPOD classes 2 and 3, while outcome parameters remained stable in eyes of class 1. CONCLUSIONS The results indicate that MPOD and its distribution may serve as a prognostic marker for disease progression and functional impairment in patients with MacTel.

Type: Article
Title: Macular Pigment Distribution as Prognostic Marker for Disease Progression in Macular Telangiectasia Type 2
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.ajo.2018.07.017
Publisher version: https://doi.org/10.1016/j.ajo.2018.07.017
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/10090988
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