Dickenson, AH;
Patel, R;
(2020)
Translational issues in precision medicine in neuropathic pain.
Canadian Journal of Pain
, 4
(1)
pp. 30-38.
10.1080/24740527.2020.1720502.
Preview |
Text
Patel_Translational issues in precision medicine in neuropathic pain.pdf - Published Version Download (1MB) | Preview |
Abstract
Neuropathic pain remains poorly treated with most new drugs falling through the translational gap. The traditional model of bench-to-bedside research has relied on identifying new mechanisms/targets in animal models and then developing clinical applications. Several have advocated bridging the translational gap by beginning with clinical observations and back-translating to animal models for further investigation of mechanisms. There is good evidence that phenotyping of patients through quantitative sensory testing can lead to improved treatment selection and hence improved patient outcomes. These practices have been widely adopted in clinical investigations but its application in pre-clinical research is not mainstream. In this review, we retrospectively examine our historical rodent datasets with the aim of reconsidering drug effects on sensory neuronal endpoints, their alignment with clinical observations and how these might guide future clinical studies.
| Type: | Article |
|---|---|
| Title: | Translational issues in precision medicine in neuropathic pain |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1080/24740527.2020.1720502 |
| Publisher version: | https://doi.org/10.1080/24740527.2020.1720502 |
| Language: | English |
| Additional information: | © 2020 The Author(s). Published with license by Taylor & Francis Group, LLC. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | Translational research, neuropathic pain, sensory phenotype, precision medicine, animal models of neuropathy |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10090484 |
Archive Staff Only
 |
View Item |
