Homan, P;
Lin, Q;
Murrough, JW;
Soleimani, L;
Bach, DR;
Clem, RL;
Schiller, D;
(2017)
Prazosin during threat discrimination boosts memory of the safe stimulus.
Learning & Memory
, 24
(11)
pp. 597-601.
10.1101/lm.045898.117.
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Abstract
The α-1 adrenoreceptor antagonist prazosin has shown promise in the treatment of post-traumatic stress disorder (PTSD) symptoms, but its mechanisms are not well understood. Here we administered prazosin or placebo prior to threat conditioning (day 1) and tested subsequent extinction (day 2) and reextinction (day 3) in healthy human participants. Prazosin did not affect threat conditioning but augmented stimulus discrimination during extinction and reextinction, via lower responding to the safe stimulus. These results suggest that prazosin during threat acquisition may have influenced encoding or consolidation of safety processing in particular, subsequently leading to enhanced discrimination between the safe and threatening stimuli.
| Type: | Article |
|---|---|
| Title: | Prazosin during threat discrimination boosts memory of the safe stimulus |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1101/lm.045898.117 |
| Publisher version: | https://doi.org/10.1101/lm.045898.117 |
| Language: | English |
| Additional information: | This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first 12 months after the full-issue publication date (see http://learnmem.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/. |
| Keywords: | Science & Technology, Social Sciences, Life Sciences & Biomedicine, Neurosciences, Psychology, Experimental, Neurosciences & Neurology, Psychology, POSTTRAUMATIC-STRESS-DISORDER, SKIN-CONDUCTANCE RESPONSES, LONG-TERM POTENTIATION, CONDITIONED FEAR, COMBAT VETERANS, SLEEP DISTURBANCES, TRAUMA NIGHTMARES, EXTINCTION, PLACEBO, AMYGDALA |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10090434 |
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