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Vagal sensory neurons drive mucous cell metaplasia

Talbot, S; Doyle, B; Huang, J; Wang, J-C; Ahmadi, M; Roberson, DP; Yekkirala, A; ... Woolf, CJ; + view all (2020) Vagal sensory neurons drive mucous cell metaplasia. Journal of Allergy and Clinical Immunology , 145 (6) pp. 1693-1694. 10.1016/j.jaci.2020.01.003. Green open access

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Abstract

Summary: Airway sensory neuron-produced Substance P heightens allergy-induced goblet cell hyperplasia and hypersecretion of Muc5AC, electrically silencing these overreactive neurons reduced these components of lung type 2 allergic inflammatory response.

Type: Article
Title: Vagal sensory neurons drive mucous cell metaplasia
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.jaci.2020.01.003
Publisher version: https://doi.org/10.1016/j.jaci.2020.01.003
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Vagal sensory neurons, TRPV1, QX-314, Optogenetic, Mucous metaplasia, Goblet cell hyperplasia, Substance P, Muc5AC, Muc5B, Asthma
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Wolfson Inst for Biomedical Research
URI: https://discovery.ucl.ac.uk/id/eprint/10090324
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