Rajani, RM;
Williams, A;
(2017)
Endothelial cell–oligodendrocyte interactions in small vessel disease and aging.
Clinical Science
, 131
(5)
pp. 369-379.
10.1042/CS20160618.
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Abstract
Cerebral small vessel disease (SVD) is a prevalent, neurological disease that significantly increases the risk of stroke and dementia. The main pathological changes are vascular, in the form of lipohyalinosis and arteriosclerosis, and in the white matter (WM), in the form of WM lesions. Despite this, it is unclear to what extent the key cell types involved – the endothelial cells (ECs) of the vasculature and the oligodendrocytes of the WM – interact. Here, we describe the work that has so far been carried out suggesting an interaction between ECs and oligodendrocytes in SVD. As these interactions have been studied in more detail in other disease states and in development, we explore these systems and discuss the role these mechanisms may play in SVD.
| Type: | Article |
|---|---|
| Title: | Endothelial cell–oligodendrocyte interactions in small vessel disease and aging |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1042/CS20160618 |
| Publisher version: | http://dx.doi.org/10.1042/CS20160618 |
| Language: | English |
| Additional information: | © 2017 The Author(s) This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution Licence 4.0 (CC BY). https://creativecommons.org/licenses/by/4.0/ |
| Keywords: | dementia, endothelial cells, myelin, oligodendrocytes, small vessel disease |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > UK Dementia Research Institute |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10090170 |
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