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Active screen plasma nitriding enhances cell attachment to polymer surfaces

Kaklamani, G; Bowen, J; Mehrban, N; Dong, H; Grover, LM; Stamboulis, A; (2013) Active screen plasma nitriding enhances cell attachment to polymer surfaces. Applied Surface Science , 273 pp. 787-798. 10.1016/j.apsusc.2013.03.001. Green open access

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Abstract

Active screen plasma nitriding (ASPN) is a well-established technique used for the surface modification of materials, the result of which is often a product with enhanced functional performance. Here we report the modification of the chemical and mechanical properties of ultra-high molecular weight poly(ethylene) (UHMWPE) using 80:20 (v/v) N2/H2 ASPN, followed by growth of 3T3 fibroblasts on the treated and untreated polymer surfaces. ASPN-treated UHMWPE showed extensive fibroblast attachment within 3 h of seeding, whereas fibroblasts did not successfully attach to untreated UHMWPE. Fibroblast-coated surfaces were maintained for up to 28 days, monitoring their metabolic activity and morphology throughout. The chemical properties of the ASPN-treated UHMWPE surface were studied using X-ray photoelectron spectroscopy, revealing the presence of CN, CN, and CN chemical bonds. The elastic modulus, surface topography, and adhesion properties of the ASPN-treated UHMWPE surface were studied over 28 days during sample storage under ambient conditions and during immersion in two commonly used cell culture media.

Type: Article
Title: Active screen plasma nitriding enhances cell attachment to polymer surfaces
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.apsusc.2013.03.001
Publisher version: https://doi.org/10.1016/j.apsusc.2013.03.001
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Active screen plasma nitriding, Atomic force microscopy, Fibroblast, Interferometry, Nanoindentation, X-ray photoelectron spectroscopy
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > The Ear Institute
URI: https://discovery.ucl.ac.uk/id/eprint/10089840
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