Flavin-containing monooxygenases: new structures from old proteins

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Flavin-containing monooxygenases: new structures from old proteins

Phillips, IR; Shephard, EA; (2020) Flavin-containing monooxygenases: new structures from old proteins. Nature Structural & Molecular Biology , 27 pp. 3-4. 10.1038/s41594-019-0356-1. Green open access

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Abstract

A study reports the structures of membrane-bound flavin-containing monooxygenases (FMOs), solved using reconstructed ancestral mammalian FMOs. The models provide a structural basis for these enzymes’ mechanism of action and show how the proteins interact with membranes and how substrates access their active sites.

Type:	Article
Title:	Flavin-containing monooxygenases: new structures from old proteins
Location:	United States
Open access status:	An open access version is available from UCL Discovery
DOI:	10.1038/s41594-019-0356-1
Publisher version:	https://doi.org/10.1038/s41594-019-0356-1
Language:	English
Additional information:	This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords:	Enzyme mechanisms, Enzymes, Evolution, Structure determination, X-ray crystallography
UCL classification:	UCL UCL > Provost and Vice Provost Offices UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology
URI:	https://discovery.ucl.ac.uk/id/eprint/10089814