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Cerebrospinal fluid levels of neurogranin in Parkinsonian disorders

Hall, S; Janelidze, S; Zetterberg, H; Brix, B; Mattsson, N; Surova, Y; Blennow, K; (2019) Cerebrospinal fluid levels of neurogranin in Parkinsonian disorders. Movement Disorders 10.1002/mds.27950. (In press).

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Abstract

Background: CSF concentration of neurogranin has been suggested as a biomarker for synapse dysfunction. / Objectives: To investigate CSF neurogranin in parkinsonian disorders compared to controls and Alzheimer's disease and the possible correlations between neurogranin and cognitive and motor impairment. / Methods: We included 157 patients with PD, 29 with PD with dementia, 11 with dementia with Lewy bodies, 26 with MSA, 21 with PSP, 6 with corticobasal syndrome, 47 controls, and 124 with Alzheimer's disease. CSF neurogranin was measured using two enzyme‐linked immunosorbent assays; from EUROIMMUN and the University of Gothenburg. / Results: We found a strong correlation between CSF neurogranin‐EI and CSF neurogranin–University of Gothenburg (Rs = 0.890; P < 0.001). Neurogranin was decreased in PD, PD with dementia, MSA, and PSP compared to controls and Alzheimer's disease. Neurogranin did not correlate with motor or cognitive impairment, longitudinal decline, or progression to dementia in PD. / Conclusions: CSF neurogranin is decreased in parkinsonian disorders compared to controls, emphasizing the importance of synaptic dysfunction in these disorders.

Type: Article
Title: Cerebrospinal fluid levels of neurogranin in Parkinsonian disorders
DOI: 10.1002/mds.27950
Publisher version: https://doi.org/10.1002/mds.27950
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: cerebrospinal fluid, neurogranin, parkinsonian disorders
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/10089792
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