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Low Cost Fabrication of PVA Based Personalized Vascular Phantoms for in Vitro Haemodynamic Studies: Three Applications

Annio, G; Franzetti, G; Bonfanti, M; Gallarello, A; Palombi, A; De Momi, E; Homer-Vanniasinkam, S; ... Burriesci, G; + view all (2020) Low Cost Fabrication of PVA Based Personalized Vascular Phantoms for in Vitro Haemodynamic Studies: Three Applications. Journal of Engineering and Science in Medical Diagnostics and Therapy , 3 (3) , Article 034501. 10.1115/1.4045760. Green open access

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Abstract

Vascular phantoms mimicking human vessels are commonly used to perform in vitro haemodynamic studies for a number of bioengineering applications, such as medical device testing, clinical simulators and medical imaging research. Simplified geometries are useful to perform parametric studies, but accurate representations of the complexity of the in vivo system are essential in several applications as personalised features have been found to play a crucial role in the management and treatment of many vascular pathologies. Despite numerous studies employing vascular phantoms produced through different manufacturing techniques, an economically viable technique, able to generate large complex patient-specific vascular anatomies, still needs to be identified. In this work, a manufacturing framework to create personalised and complex phantoms with easily accessible and affordable materials is presented. In particular, 3D printing with polyvinyl alcohol (PVA) is employed to create the mould, and lost core casting is performed to create the physical model. The applicability and flexibility of the proposed fabrication protocol is demonstrated through three phantom case studies - an idealised aortic arch, a patient-specific aortic arch, and a patient-specific aortic dissection model. The phantoms were successfully manufactured in a rigid silicone, a compliant silicone and a rigid epoxy resin, respectively; using two different 3D printers and two casting techniques, without the need of specialist equipment.

Type: Article
Title: Low Cost Fabrication of PVA Based Personalized Vascular Phantoms for in Vitro Haemodynamic Studies: Three Applications
Open access status: An open access version is available from UCL Discovery
DOI: 10.1115/1.4045760
Publisher version: https://doi.org/10.1115/1.4045760
Language: English
Additional information: This version is the author accepted manuscript. Copyright © ASME; CC-BY distribution license (https://creativecommons.org/licenses/by/4.0/).
Keywords: Hemodynamics, Manufacturing, Phantoms, Aortic arch, Casting, Silicones, Additive manufacturing, Bioengineering, Biomedical imaging, Epoxy resins, Ethanol, Medical devices, Testing, Vessels
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/10089725
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