Simoncelli, S;
Johnson, S;
Kriegel, F;
Lipfert, J;
Feldmann, J;
(2017)
Stretching and Heating Single DNA Molecules with Optically Trapped Gold-Silica Janus Particles.
ACS Photonics
, 4
(11)
pp. 2843-2851.
10.1021/acsphotonics.7b00839.
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Abstract
Self-propelled micro- and nanoscale motors are capable of autonomous motion typically by inducing local concentration gradients or thermal gradients in their surrounding medium. This is a result of the heterogeneous surface of the self-propelled structures that consist of materials with different chemical or physical properties. Here we present a self-thermophoretically driven Au–silica Janus particle that can simultaneously stretch and partially melt a single double-stranded DNA molecule. We show that the effective force acting on the DNA molecule is in the ∼pN range, well suited to probe the entropic stretching regime of DNA, and we demonstrate that the local temperature enhancement around the gold side of the particle produces partial DNA dehybridization.
Type: | Article |
---|---|
Title: | Stretching and Heating Single DNA Molecules with Optically Trapped Gold-Silica Janus Particles |
Open access status: | An open access version is available from UCL Discovery |
DOI: | 10.1021/acsphotonics.7b00839 |
Publisher version: | https://doi.org/10.1021/acsphotonics.7b00839 |
Language: | English |
Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
Keywords: | self-thermophoresis Janus particles optical trapping DNA stretching DNA dehybridization pN forces |
UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > London Centre for Nanotechnology |
URI: | https://discovery.ucl.ac.uk/id/eprint/10089456 |
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