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Neuroimaging correlates of false memory in 'Alzheimer's disease: A preliminary systematic review

McLachlan, E; Rai, S; Al-Shihabi, A; Huntley, J; Burgess, N; Howard, R; Reeves, S; (2020) Neuroimaging correlates of false memory in 'Alzheimer's disease: A preliminary systematic review. Psychiatry Research: Neuroimaging , 296 , Article 111021. 10.1016/j.pscychresns.2019.111021. Green open access

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Abstract

Alzheimer's disease (AD) is characterised by episodic memory impairment, but people also experience memory distortions, including false memories, which can impact on safety and reduce functioning. Understanding the neural networks that underpin false memories could help to predict the need for intervention and guide development of cognitive strategies to reduce memory errors. However, there is a relative absence of research into how the neuropathology of AD contributes to false memory generation. This paper systematically reviews the methodology and outcomes of studies investigating the neuroimaging correlates of false memory in AD. Four studies using structural imaging and three studies using functional imaging were identified. Studies were heterogenous in methodology and received mostly ‘weak’ quality assessment ratings. Combined, and consistent with neuroimaging findings in non-AD populations, results from identified studies provide preliminary support for the hypothesis that medial temporal lobe and prefrontal cortex dysfunction may lead to generation of false memories in AD. However, the small number of studies and significant heterogeneity within them means further study is necessary to assess replicability of results.

Type: Article
Title: Neuroimaging correlates of false memory in 'Alzheimer's disease: A preliminary systematic review
Location: Netherlands
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.pscychresns.2019.111021
Publisher version: https://doi.org/10.1016/j.pscychresns.2019.111021
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Alzheimer's disease, Confabulation, False memory, Neuroimaging
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Experimental Epilepsy
URI: https://discovery.ucl.ac.uk/id/eprint/10089236
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