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Implant materials and prosthetic joint infection: the battle with the biofilm

Davidson, DJ; Spratt, D; Liddle, AD; (2019) Implant materials and prosthetic joint infection: the battle with the biofilm. EFORT Open Reviews , 4 (11) pp. 633-639. 10.1302/2058-5241.4.180095. Green open access

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Abstract

Prosthetic joint infection (PJI) is associated with poor clinical outcomes and is expensive to treat.Although uncommon overall (affecting between 0.5% and 2.2% of cases), PJI is one of the most commonly encountered complications of joint replacement and its incidence is increasing, putting a significant burden on healthcare systems.Once established, PJI is extremely difficult to eradicate as bacteria exist in biofilms which protect them from antibiotics and the host immune response.Improved understanding of the microbial pathology in PJI has generated potential new treatment strategies for prevention and eradication of biofilm associated infection including modification of implant surfaces to prevent adhesion of bacteria.Much research is currently ongoing looking at different implant surface coatings and modifications, and although most of this work has not translated into clinical medicine there has been some early clinical success. Cite this article: EFORT Open Rev 2019;4:633-639. DOI: 10.1302/2058-5241.4.180095.

Type: Article
Title: Implant materials and prosthetic joint infection: the battle with the biofilm
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1302/2058-5241.4.180095
Publisher version: https://doi.org/10.1302/2058-5241.4.180095
Language: English
Additional information: © 2019 The Author(s). This article is distributed under the terms of the Creative Commons Attribution-Non Commercial 4.0 International (CC BY-NC 4.0) licence (https://creativecommons.org/ licenses/by-nc/4.0/).
Keywords: biofilm, implant, material, microbiology, prosthetic joint infection, surface coating
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > Microbial Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/10089207
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