Bale, G;
Rajaram, A;
Kewin, M;
Morrison, L;
Bainbridge, A;
Liu, L;
Anazodo, U;
... Tachtsidis, I; + view all
(2019)
Multimodal measurements of brain tissue metabolism and perfusion in a neonatal model of hypoxic-ischaemic injury.
In: Dehghani, H and Wabnitz, H, (eds.)
Diffuse Optical Spectroscopy and Imaging VII.
SPIE: Munich, Germany.
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Abstract
This is the first multimodal study of cerebral tissue metabolism and perfusion post-hypoxic-ischaemic (HI) brain injury with broadband near-infrared spectroscopy (bNIRS), diffuse correlation spectroscopy (DCS), positron emission tomography (PET) and magnetic resonance spectroscopy (MRS). In 5 piglet models of HI, we measured cerebral tissue saturation (StO2), cerebral blood flow (CBF), cerebral oxygen metabolism (CMRO2), changes in the mitochondrial oxidation state of cytochrome-c-oxidase (oxCCO), cerebral glucose metabolism (CMRglc), and tissue biochemistry (Lac+Thr/tNAA). At baseline, the parameters measured were: 64±6 % StO2, 35±11 ml/100g/min CBF, and 2.0±0.4 μmol/100g/min CMRO2. After HI the parameters measured were: 68±6% StO2, 35±6 ml/100g/min CBF, 1.3±0.1 μmol/100g/min CMRO2, 0.4±0.2 Lac+Thr/tNAA, and 9.5±2.0 CMRglc. This study demonstrates the capacity of a multimodal set up to interrogate the pathophysiology of HIE using a combination of optical methods, MRS, and PET.
| Type: | Proceedings paper |
|---|---|
| Title: | Multimodal measurements of brain tissue metabolism and perfusion in a neonatal model of hypoxic-ischaemic injury |
| Event: | European Conferences on Biomedical Optics, 2019 |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1117/12.2526729 |
| Publisher version: | https://doi.org/10.1117/12.2526729 |
| Language: | English |
| Additional information: | This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10089137 |
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