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Fluency and rule breaking behaviour in the frontal cortex

Cipolotti, L; Molenberghs, P; Dominguez, J; Smith, N; Smirni, D; Xu, T; Shallice, T; (2020) Fluency and rule breaking behaviour in the frontal cortex. Neuropsychologia , 137 , Article 107308. 10.1016/j.neuropsychologia.2019.107308. Green open access

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Abstract

Design (DF) and phonemic fluency tests (FAS; D-KEFS, 2001) are; commonly used to investigate voluntary generation. Despite this, several; important issues remain poorly investigated. In a sizeable sample of; patients with focal left or right frontal lesion we established that; voluntary generation performance cannot be accounted for by fluid; intelligence. For DF we found patients performed significantly worse than; healthy controls (HC) only on the switch condition. However, no significant difference between left and right frontal patients was found. In contrast, left frontal patients were significantly impaired when compared with HC and right frontal patients on FAS. These lateralization findings were complemented, for the first time, by three neuroimaging; investigations. A traditional frontal subgrouping method found; significant differences on FAS between patients with or without Left Inferior Frontal Gyrus lesions involving BA 44 and/or 45. Parcel Based Lesion Symptom Mapping (PLSM) found lower scores on FAS were significantly associated with damage to posterior Left Middle Frontal Gyrus. An increase in rule break errors, so far only anecdotally reported, was associated with damage to the left dorsal anterior cingulate and left body of the corpus callosum, supporting the idea that conflict resolution and monitoring impairments may play a role. Tractwise statistical analysis (TSA) revealed that patients with disconnection; in the left anterior thalamic projections, frontal aslant tract, frontal; orbitopolar tract, pons, superior longitudinal fasciculus I and II performed significantly worse than patients without disconnection in these tracts on FAS. In contrast, PLSM and TSA analyses did not reveal any significant relationship between lesion location and performance on the DF switch condition. Overall, these findings suggest DF may have limited utility as a tool in detecting lateralized frontal executive dysfunction, whereas FAS and rule break behavior appears to be linked to a set of well localized left frontal grey matter regions and white matter tracts.

Type: Article
Title: Fluency and rule breaking behaviour in the frontal cortex
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.neuropsychologia.2019.107308
Publisher version: https://doi.org/10.1016/j.neuropsychologia.2019.10...
Language: English
Additional information: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Keywords: Executive, Fluid intelligence, Functions, Parcel based lesion symptom mapping tract-wise statistical analysis, Phonemic and design fluency, Prefrontal cortex, Rule break errors
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Brain Repair and Rehabilitation
URI: https://discovery.ucl.ac.uk/id/eprint/10089112
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