UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Women's choices in non-invasive prenatal testing for aneuploidy screening: results from a single centre prior to introduction in England

Sacco, A; Hewitt, H; Pandya, P; (2020) Women's choices in non-invasive prenatal testing for aneuploidy screening: results from a single centre prior to introduction in England. Archives of Disease in Childhood , 105 (1) pp. 47-52. 10.1136/archdischild-2019-317031. Green open access

[img]
Preview
Text
Sacco NIPT paper main text ADC revised.pdf - Accepted version

Download (528kB) | Preview

Abstract

OBJECTIVE: To evaluate patient choices and uptake of non-invasive prenatal testing (NIPT) for aneuploidy screening offered in a contingency model as part of routine care. METHOD: We retrospectively reviewed data for all women with a singleton pregnancy attending for routine first trimester screening over an 18-month period. Women with a 'high-chance' of trisomy 21, 18 or 13 (≥1:150) were offered the choice of no further testing, NIPT or invasive testing, in line with the screening pathway recommended by the UK National Screening Committee. RESULTS: Of 9342 women attending for a first trimester ultrasound scan, 7939 women were included in this study. Of these, 352 had a high-chance screening result for trisomy 21, and 291 (82.7%) opted for NIPT. The proportion of women opting for NIPT decreased as the chance of trisomy 21 increased: uptake was 93.2%, 90.0%, 77.1% and 47.2% for women with a chance of 1:100-150, 1:50-99, 1:10-49 and >1:10, respectively. 516 women (5.5%) accessed primary NIPT screening in the private sector, and 638 women (6.8%) declined any aneuploidy screening or testing. CONCLUSION: Implementation of NIPT testing in a contingency model has a high uptake in a non-research National Health Service setting; the rate of uptake is related to the combined test risk result.

Type: Article
Title: Women's choices in non-invasive prenatal testing for aneuploidy screening: results from a single centre prior to introduction in England
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1136/archdischild-2019-317031
Publisher version: https://doi.org/10.1136/archdischild-2019-317031
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Down’s syndrome, NIPT, aneuploidy, screening
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Maternal and Fetal Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/10088890
Downloads since deposit
193Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item