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Predictive role of BNP/NT-proBNP in non-heart failure patients undergoing catheter ablation for atrial fibrillation: An updated systematic review

Papageorgiou, N; Providência, R; Falconer, D; Wongwarawipat, T; Tousoulis, D; Lim, WY; Chow, AW; ... Lambiase, PD; + view all (2020) Predictive role of BNP/NT-proBNP in non-heart failure patients undergoing catheter ablation for atrial fibrillation: An updated systematic review. Current Medicinal Chemistry , 27 (27) pp. 4469-4478. 10.2174/0929867326666191213095554. Green open access

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Abstract

Atrial fibrillation (AF) is a growing public health issue, associated with significant morbidity and mortality. In addition to pharmacological therapy, catheter ablation is an effective strategy in restoring and maintaining sinus rhythm. However, ablation is not without risk, and AF recurs in a significant proportion of patients. Non-invasive, easily accessible markers or indices that could stratify patients depending on the likelihood of a successful outcome following ablation would allow us to select the most appropriate patients for the procedure, reducing the AF recurrence rate and exposure to potentially life-threatening risks. There has been much attention paid to brain natriuretic peptide (BNP) and N-terminal prohormone of brain natriuretic peptide (NT-proBNP) as possible predictive markers of successful ablation. Several studies have demonstrated an association between higher pre-ablation levels of these peptides, and a greater likelihood of AF recurrence. Therefore, there may be a role for measuring brain natriuretic peptides levels when selecting patients for catheter ablation.

Type: Article
Title: Predictive role of BNP/NT-proBNP in non-heart failure patients undergoing catheter ablation for atrial fibrillation: An updated systematic review
Location: United Arab Emirates
Open access status: An open access version is available from UCL Discovery
DOI: 10.2174/0929867326666191213095554
Publisher version: http://doi.org/10.2174/0929867326666191213095554
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Ablation, Atrial Fibrillation, Brain Natriuretic Peptide, N-Terminal BNP, Recurrence, RecurrenceAtrial Fibrillation
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Clinical Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Health Informatics
URI: https://discovery.ucl.ac.uk/id/eprint/10088849
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