Ruiz-Meana, M;
Boengler, K;
Garcia-Dorado, D;
Hausenloy, DJ;
Kaambre, T;
Kararigas, G;
Perrino, C;
... Ytrehus, K; + view all
(2020)
Ageing, sex and cardioprotection.
British Journal of Pharmacology
, 177
(23)
pp. 5270-5286.
10.1111/bph.14951.
Preview |
Text
Ruiz-Meana_et_al-2019-British_Journal_of_Pharmacology.pdf - Accepted Version Download (1MB) | Preview |
Abstract
Translation of cardioprotective interventions aimed at reducing myocardial injury during ischaemia-reperfusion from experimental studies to clinical practice is an important yet unmet need in cardiovascular medicine. One particular challenge facing translation is the existence of demographic and clinical factors that influence the pathophysiology of ischaemia-reperfusion injury of the heart and the effects of treatments aimed at preventing it. Among these factors, age and sex are prominent and have a recognised role in the susceptibility and outcome of ischaemic heart disease. Remarkably, some of the most powerful cardioprotective strategies proven to be effective in young animals become ineffective during ageing. This article reviews the mechanisms and implications of the modulatory effects of ageing and sex on myocardial ischaemia-reperfusion injury and their potential effects on cardioprotective interventions.
| Type: | Article |
|---|---|
| Title: | Ageing, sex and cardioprotection |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/bph.14951 |
| Publisher version: | https://doi.org/10.1111/bph.14951 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Pre-clinical and Fundamental Science |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10088820 |
Archive Staff Only
 |
View Item |
