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Lifetime cardiovascular management of patients with previous Kawasaki disease

Brogan, P; Burns, JC; Cornish, J; Diwakar, V; Eleftheriou, D; Gordon, JB; Gray, HH; ... Tulloh, RMR; + view all (2019) Lifetime cardiovascular management of patients with previous Kawasaki disease. Heart 10.1136/heartjnl-2019-315925. (In press). Green open access

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Abstract

Kawasaki disease (KD) is an inflammatory disorder of young children, associated with vasculitis of the coronary arteries with subsequent aneurysm formation in up to one-third of untreated patients. Those who develop aneurysms are at life-long risk of coronary thrombosis or the development of stenotic lesions, which may lead to myocardial ischaemia, infarction or death. The incidence of KD is increasing worldwide, and in more economically developed countries, KD is now the most common cause of acquired heart disease in children. However, many clinicians in the UK are unaware of the disorder and its long-term cardiac complications, potentially leading to late diagnosis, delayed treatment and poorer outcomes. Increasing numbers of patients who suffered KD in childhood are transitioning to the care of adult services where there is significantly less awareness and experience of the condition than in paediatric services. The aim of this document is to provide guidance on the long-term management of patients who have vascular complications of KD and guidance on the emergency management of acute coronary complications. Guidance on the management of acute KD is published elsewhere.

Type: Article
Title: Lifetime cardiovascular management of patients with previous Kawasaki disease
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1136/heartjnl-2019-315925
Publisher version: http://dx.doi.org/10.1136/heartjnl-2019-315925
Language: English
Additional information: © Author(s) (or their employer[s]) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license (http://creativecommons.org/licenses/by-nc/4.0/).
Keywords: Kawasaki disease, acute coronary syndrome, cardiovascular risk, coronary artery aneurysm, late sequelae, lifetime cardiovascular management, person specific protocol, transitional care
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept
URI: https://discovery.ucl.ac.uk/id/eprint/10088807
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