UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Ethnic Variation in the Manifestation of Parkinson's Disease: A Narrative Review

Ben-Joseph, A; Marshall, CR; Lees, AJ; Noyce, AJ; (2020) Ethnic Variation in the Manifestation of Parkinson's Disease: A Narrative Review. Journal of Parkinson's Disease , 10 (1) pp. 31-45. 10.3233/JPD-191763. Green open access

[thumbnail of Noyce jpd-prepress_jpd--1--1-jpd191763_jpd--1-jpd191763.pdf]
Preview
Text
Noyce jpd-prepress_jpd--1--1-jpd191763_jpd--1-jpd191763.pdf - Accepted version

Download (142kB) | Preview

Abstract

The global prevalence of Parkinson’s disease is increasing, yet the characteristics, risk factors and genetics of PD in Black, Asian and Hispanic populations is little understood. In this paper we review the published literature on clinical variation in the symptoms and signs of Parkinson’s disease in different ethnic groups and responses to treatment. We included any study that sampled patients with Parkinson’s disease from distinct ethnic backgrounds. We conclude that whilst there is little published evidence for ethnic variation in the clinical features of Parkinson’s disease, there are substantial limitations and gaps in the current literature, which mean that the evidence does necessarily not fit with clinical observation. Possible explanations for expected differences in manifestation include genetic determinants, the co-existence of cerebrovascular disease and/or Alzheimer’s disease pathology, healthcare inequalities and socio-cultural factors.

Type: Article
Title: Ethnic Variation in the Manifestation of Parkinson's Disease: A Narrative Review
Location: Netherlands
Open access status: An open access version is available from UCL Discovery
DOI: 10.3233/JPD-191763
Publisher version: https://doi.org/10.3233/JPD-191763
Language: English
Additional information: This article is published online with Open Access and distributed under the terms of the Creative Commons Attribution Non-Commercial License (CC BY-NC 4.0). https://creativecommons.org/licenses/by-nc/4.0/
Keywords: Parkinson’s disease, ethnic groups, epidemiology, tremor, dementia, atypical parkinsonism
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
URI: https://discovery.ucl.ac.uk/id/eprint/10088686
Downloads since deposit
28Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item