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How to approach a patient with parkinsonism – red flags for atypical parkinsonism

Mulroy, E; Stamelou, M; Bhatia, KP; (2019) How to approach a patient with parkinsonism – red flags for atypical parkinsonism. International Review of Neurobiology , 149 pp. 1-34. 10.1016/bs.irn.2019.10.001.

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Abstract

Parkinsonism is a clinical syndrome defined by bradykinesia plus rigidity or tremor. Though most commonly encountered in the setting of idiopathic Parkinson's disease, a number of neurodegenerative, structural, metabolic and toxic neurological disorders can result in parkinsonism. Accurately diagnosing the underlying cause of parkinsonism is of both therapeutic and prognostic relevance, especially as we enter the era of disease-modifying treatment trials for neurodegenerative disorders. Being aware of the wide array of potential causes of parkinsonism is of paramount importance for clinicians. In this chapter, we present a pragmatic clinical approach to patients with parkinsonism, specifically focusing on ‘red flags’, which should alert one to consider diagnoses other than idiopathic Parkinson's disease.

Type: Article
Title: How to approach a patient with parkinsonism – red flags for atypical parkinsonism
Location: United States
DOI: 10.1016/bs.irn.2019.10.001
Publisher version: https://doi.org/10.1016/bs.irn.2019.10.001
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Atypical parkinsonian disorders, Lewy body disease, Multiple system atrophy, Parkinson disease, Red flags, Supranuclear palsy
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/10088553
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