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The expanding spectrum of movement disorders in genetic epilepsies

Papandreou, A; Danti, FR; Spaull, R; Leuzzi, V; Mctague, A; Kurian, MA; (2020) The expanding spectrum of movement disorders in genetic epilepsies. Developmental Medicine & Child Neurology , 62 (2) pp. 178-191. 10.1111/dmcn.14407. Green open access

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Abstract

An ever‐increasing number of neurogenetic conditions presenting with both epilepsy and atypical movements are now recognized. These disorders within the ‘genetic epilepsy‐dyskinesia’ spectrum are clinically and genetically heterogeneous. Increased clinical awareness is therefore necessary for a rational diagnostic approach. Furthermore, careful interpretation of genetic results is key to establishing the correct diagnosis and initiating disease‐specific management strategies in a timely fashion. In this review we describe the spectrum of movement disorders associated with genetically determined epilepsies. We also propose diagnostic strategies and putative pathogenic mechanisms causing these complex syndromes associated with both seizures and atypical motor control.

Type: Article
Title: The expanding spectrum of movement disorders in genetic epilepsies
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/dmcn.14407
Publisher version: https://doi.org/10.1111/dmcn.14407
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Neurosciences Dept
URI: https://discovery.ucl.ac.uk/id/eprint/10088482
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