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Consensus-based technical recommendations for clinical translation of renal ASL MRI

Nery, F; Buchanan, CE; Harteveld, AA; Odudu, A; Bane, O; Cox, EF; Derlin, K; ... Fernández-Seara, MA; + view all (2019) Consensus-based technical recommendations for clinical translation of renal ASL MRI. Magnetic Resonance Materials in Physics, Biology and Medicine 10.1007/s10334-019-00800-z. (In press). Green open access

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Abstract

OBJECTIVES: This study aimed at developing technical recommendations for the acquisition, processing and analysis of renal ASL data in the human kidney at 1.5 T and 3 T field strengths that can promote standardization of renal perfusion measurements and facilitate the comparability of results across scanners and in multi-centre clinical studies. METHODS: An international panel of 23 renal ASL experts followed a modified Delphi process, including on-line surveys and two in-person meetings, to formulate a series of consensus statements regarding patient preparation, hardware, acquisition protocol, analysis steps and data reporting. RESULTS: Fifty-nine statements achieved consensus, while agreement could not be reached on two statements related to patient preparation. As a default protocol, the panel recommends pseudo-continuous (PCASL) or flow-sensitive alternating inversion recovery (FAIR) labelling with a single-slice spin-echo EPI readout with background suppression and a simple but robust quantification model. DISCUSSION: This approach is considered robust and reproducible and can provide renal perfusion images of adequate quality and SNR for most applications. If extended kidney coverage is desirable, a 2D multislice readout is recommended. These recommendations are based on current available evidence and expert opinion. Nonetheless they are expected to be updated as more data become available, since the renal ASL literature is rapidly expanding.

Type: Article
Title: Consensus-based technical recommendations for clinical translation of renal ASL MRI
Location: Germany
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/s10334-019-00800-z
Publisher version: https://doi.org/10.1007/s10334-019-00800-z
Language: English
Additional information: Copyright © The Author(s) 2019. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Keywords: Arterial spin labelling, Kidney, MRI, Perfusion, Renal blood flow
UCL classification: UCL
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URI: https://discovery.ucl.ac.uk/id/eprint/10088467
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