Yu, B;
Steptoe, A;
Chen, L-J;
Chen, Y-H;
Lin, C-H;
Ku, P-W;
(2020)
Social isolation, Loneliness and All-cause Mortality in Patients with Cardiovascular Disease: A 10-year Follow-up Study.
Psychosomatic Medicine
, 82
(2)
pp. 208-214.
10.1097/PSY.0000000000000777.
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Abstract
OBJECTIVE: Social isolation and loneliness have been associated with increased incidence of cardiovascular disease (CVD), but few studies have evaluated the impact of social isolation and loneliness on mortality in people with existing CVD, and these are limited to Western populations. We examined whether social isolation and loneliness associated with increased risk of mortality in individuals with established CVD in Taiwan. METHODS: The cohort was composed of 1,267 patients with confirmed CVD aged 65 years or older followed up for up to 10 years. Cox proportional hazard regression models were used to examine the association between social isolation and loneliness at baseline and mortality at follow-up by adjusting for demographic variables, health-related behaviors, and health status. RESULTS: There were 593 deaths over the follow-up period. Social isolation was associated with increased risk of mortality after accounting for established risk factors (hazard ratio [HR]=1.16; 95% CI=1.06, 1.26), while loneliness was not associated with increased risk of mortality (HR=0.95; 95% CI=0.82, 1.09). When both social isolation and loneliness were included in the model, social isolation maintained an association with mortality (HR=1.16; 95% CI =1.07, 1.27). CONCLUSIONS: Social isolation is associated with an increased risk of mortality in patients with CVD, and the effects are independent of loneliness. These findings expand our knowledge about the impact of social isolation on the outcomes of CVD in non-Western countries. Efforts to reduce isolation may have substantial benefits in terms of mortality in patients with CVD.
| Type: | Article |
|---|---|
| Title: | Social isolation, Loneliness and All-cause Mortality in Patients with Cardiovascular Disease: A 10-year Follow-up Study |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1097/PSY.0000000000000777 |
| Publisher version: | https://doi.org/10.1097/PSY.0000000000000777 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | social isolation; loneliness; all-cause mortality; cardiovascular disease (CVD) |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Behavioural Science and Health |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10088462 |
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