UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Sudden sex hormone withdrawal and the effects on body composition in late pubertal adolescents with gender dysphoria

Ghelani, R; Lim, C; Brain, C; Fewtrell, M; Butler, G; (2020) Sudden sex hormone withdrawal and the effects on body composition in late pubertal adolescents with gender dysphoria. Journal of Pediatric Endocrinology and Metabolism , 33 (1) pp. 107-112. 10.1515/jpem-2019-0045. Green open access

[thumbnail of Fewtrell_Sudden sex hormone withdrawal and the effects on body composition in late pubertal adolescents with gender dysphoria_AOP.pdf]
Preview
Text
Fewtrell_Sudden sex hormone withdrawal and the effects on body composition in late pubertal adolescents with gender dysphoria_AOP.pdf - Published Version

Download (158kB) | Preview

Abstract

Background: Sex hormones initiate profound physical and physiological changes during the pubertal process, but to what extent are they responsible for continuing the body composition changes of late adolescence and what happens to body composition on sudden sex hormone withdrawal? / Methods: Thirty-six healthy, phenotypically and chromosomally normal late and post-pubertal individuals aged 15–17 years with gender dysphoria (transgirls – birth-registered males identifying as female n = 11; and transboys – birth-registered females identifying as male n = 25) underwent Tanita body composition analysis at 0, 6 and 12 months during reproductive hormone suppression with Triptorelin as part of the standard therapeutic protocol. / Results and conclusions: In the transgirl cohort, paired t-test analysis demonstrated a significant decrease in height and lean mass standard deviation scores over the 12-month period, going against an expected trajectory over that time. In contrast, oestrogen suppression appeared not to affect the body composition of transboys; their measurements were not significantly different at baseline and after 12 months of treatment. The withdrawal of sex hormone secretion does not appear to have a significant impact on female post-pubertal body composition, in contrast to that seen at the menopause. This suggests that other factors may preserve normal body balance in adolescents in the absence of sex steroids.

Type: Article
Title: Sudden sex hormone withdrawal and the effects on body composition in late pubertal adolescents with gender dysphoria
Location: Germany
Open access status: An open access version is available from UCL Discovery
DOI: 10.1515/jpem-2019-0045
Publisher version: https://doi.org/10.1515/jpem-2019-0045
Language: English
Additional information: This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: BMI, GnRHa treatment, body composition, gender dysphoria, sex hormones
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Neurosciences Dept
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Population, Policy and Practice Dept
URI: https://discovery.ucl.ac.uk/id/eprint/10088242
Downloads since deposit
387Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item