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Non-metastatic cutaneous squamous cell carcinoma treated with photodynamic therapy using intravenous mTHPC

Jerjes, W; Yousif, AA; Hamdoon, Z; Hopper, C; (2019) Non-metastatic cutaneous squamous cell carcinoma treated with photodynamic therapy using intravenous mTHPC. Photodiagnosis and Photodynamic Therapy , 28 pp. 172-176. 10.1016/j.pdpdt.2019.08.004. Green open access

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Abstract

INTRODUCTION Photodynamic therapy (PDT) is a method of treating various pathologies. In this retrospective study with prospective intent, a total of 22 patients with T1/T2 N0 cutaneous squamous cell carcinoma (SCC) were treated with intravenous mTHPC (meta-tetrahydroxyphenylchlorin) and surface illumination PDT. Comparisons with the clinical features, rate of recurrence and overall outcome were made. MATERIALS AND METHODS Surface illumination PDT was offered under local anaesthesia. 0.05 mg/kg mTHPC was administered intravenously into the midcubital vein 48 h prior to tissue illumination. A single-channel 652 nm diode laser was used for illumination and light was delivered at 20 J/cm2 per site. Lesion response evaluation was carried out according to Response Evaluation Criteria In Solid Tumors (RECIST). RESULTS Clinical assessment revealed that 16 patients had lesions of <2 cm in size (T1), while the rest were T2. No nodal involvement was identified in any of the patients. None of the patients had a locally recurrent lesion. During the 3-year follow-up, 20/22 patients had complete response (CR) and this was after one round of treatment. Two patients suffered from recurrent disease within 3 years of the follow-up, and they underwent surgical resection. CONCLUSION PDT achieved high efficacy in the treatment of T1N0 cutaneous squamous cell carcinoma with greatly reduced morbidity and disfigurement. The technique is simple, can commonly be carried out in outpatient clinics, and is highly acceptable to patients.

Type: Article
Title: Non-metastatic cutaneous squamous cell carcinoma treated with photodynamic therapy using intravenous mTHPC
Location: Netherlands
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.pdpdt.2019.08.004
Publisher version: https://doi.org/10.1016/j.pdpdt.2019.08.004
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: MTHPC, PDT, Photodynamic Therapy, SCC, Skin cancer, T1/T2 stage
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > EDI MaxFac, Diagnostic, Med and Surg Sci
URI: https://discovery.ucl.ac.uk/id/eprint/10088191
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