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Novel TMS-EEG indexes to investigate interhemispheric dynamics in humans

Casula, EP; Maiella, M; Pellicciari, MC; Porrazzini, F; D'Acunto, A; Rocchi, L; Koch, G; (2020) Novel TMS-EEG indexes to investigate interhemispheric dynamics in humans. Clinical Neurophysiology , 131 (1) pp. 70-77. 10.1016/j.clinph.2019.09.013. Green open access

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Abstract

OBJECTIVE: To validate two indexes of interhemispheric signal propagation (ISP) and balance (IHB) by combining transcranial magnetic stimulation (TMS) and electroencephalography (EEG). METHODS: We used TMS-EEG to non-invasively stimulate the two hemispheres of 50 healthy volunteers and measured interhemispheric dynamics in terms of ISP and IHB. We repeated our evaluation after three weeks to assess the reliability of our indexes. We also tested whether our TMS-EEG measures were correlated with traditional interhemispheric inhibition (IHI), as measured with motor-evoked potentials (MEPs). RESULTS: Our main results showed that ISP and IHB (1) have a high reproducibility among all the participants tested; (2) have a high test-retest reliability (3) are linearly correlated with IHI, as measured with MEPs. CONCLUSIONS: The main contribution of this study lies in the proposal of new TMS-EEG cortical measures of interhemispheric dynamics and in their validation in terms of intra- and inter-subject reliability. We also provide the first demonstration of the correlation between ISP and IHI. SIGNIFICANCE: Our results are relevant for the investigation of interhemispheric dynamics in clinical populations where MEPs are not reliable.

Type: Article
Title: Novel TMS-EEG indexes to investigate interhemispheric dynamics in humans
Location: Netherlands
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.clinph.2019.09.013
Publisher version: https://doi.org/10.1016/j.clinph.2019.09.013
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: EEG, Interhemispheric balance, Interhemispheric inhibition, TMS
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
URI: https://discovery.ucl.ac.uk/id/eprint/10087976
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