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N‐methyl‐ᴅ‐aspartate (NMDA) receptor antibodies encephalitis mimicking an autistic regression

Hacohen, Y; Wright, S; Gadian, J; Vincent, A; Lim, M; Wassmer, E; Lin, J-P; (2016) N‐methyl‐ᴅ‐aspartate (NMDA) receptor antibodies encephalitis mimicking an autistic regression. Developmental Medicine & Child Neurology , 58 (10) pp. 1092-1094. 10.1111/dmcn.13169. Green open access

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Abstract

Expressive dysphasia and mutism are common clinical features in children and adults with N‐methyl‐d‐aspartate receptor antibodies (NMDAR‐Ab) encephalitis, and are likely to result from NMDAR hypofunction. A prodromal loss of social and communication skills can typify that of an autistic regression, particularly when presenting under the age of 3 years. Here we describe two toddlers who presented with developmental regression, particularly of their social communication skills, mimicking an autistic regression, who were found to have NMDAR‐Ab in the serum and cerebrospinal fluid. Although both patients had some other neurological features, they were subtle, which resulted in delayed diagnosis of NMDAR‐Ab encephalitis. Importantly, immunotherapy was beneficial in both patients, with significant improvement of their language skills and behaviour.

Type: Article
Title: N‐methyl‐ᴅ‐aspartate (NMDA) receptor antibodies encephalitis mimicking an autistic regression
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/dmcn.13169
Publisher version: https://doi.org/10.1111/dmcn.13169
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neuroinflammation
URI: https://discovery.ucl.ac.uk/id/eprint/10087948
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