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PI3Kα in cardioprotection: Cytoskeleton, late Na+ current, and mechanism of arrhythmias

Zhabyeyev, P; Chen, X; Vanhaesebroeck, B; Oudit, GY; (2019) PI3Kα in cardioprotection: Cytoskeleton, late Na+ current, and mechanism of arrhythmias. Channels , 13 (1) pp. 520-532. 10.1080/19336950.2019.1697127. Green open access

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Abstract

PI 3-kinase α (PI3Kα) is a lipid kinase that converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-triphosphate (PIP3). PI3Kα regulates a variety of cellular processes such as nutrient sensing, cell cycle, migration, and others. Heightened activity of PI3Kα in many types of cancer made it a prime oncology drug target, but also raises concerns of possible adverse effects on the heart. Indeed, recent advances in preclinical models demonstrate an important role of PI3Kα in the control of cytoskeletal integrity, Na+ channel activity, cardioprotection, and prevention of arrhythmias.

Type: Article
Title: PI3Kα in cardioprotection: Cytoskeleton, late Na+ current, and mechanism of arrhythmias
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1080/19336950.2019.1697127
Publisher version: https://doi.org/10.1080/19336950.2019.1697127
Language: English
Additional information: This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: PI3Kα, cytoskeleton, late sodium current, arrhythmias, heart failure
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
URI: https://discovery.ucl.ac.uk/id/eprint/10087763
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