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The IFITM protein family in adaptive immunity

Yánez, DC; Ross, S; Crompton, T; (2020) The IFITM protein family in adaptive immunity. Immunology , 159 (4) pp. 365-372. 10.1111/imm.13163. Green open access

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Abstract

The family of interferon-inducible transmembrane (IFITM) proteins are small homologous proteins, localised in the plasma and endolysosomal membranes, which confer cellular resistance to many viruses. In addition, several distinct functions have been associated with different IFITM family members, including germ cell specification (IFITM1-IFITM3), osteoblast function and bone mineralisation (IFITM5) and immune functions (IFITM1-3, IFITM6). IFITM1-3 are expressed by T cells and recent experiments have shown that the IFITM proteins are directly involved in adaptive immunity and that they regulate CD4+ T helper cell differentiation in a T cell intrinsic manner. Here we review the role of the IFITM proteins in T cell differentiation and function.

Type: Article
Title: The IFITM protein family in adaptive immunity
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/imm.13163
Publisher version: https://doi.org/10.1111/imm.13163
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: IFITM, T-cell, Th1, Th2, differentiation
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept
URI: https://discovery.ucl.ac.uk/id/eprint/10087664
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