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Objective imaging biomarkers to quantify the evolution of radiation-induced lung damage

Veiga, C; Jacob, J; Yip, N; Szmul, A; Landau, D; McClelland, J; (2019) Objective imaging biomarkers to quantify the evolution of radiation-induced lung damage. In: Proceedings of the 19th International Conference on the Use of Computers in Radiation Therapy. ICCR (In press). Green open access

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Abstract

Radiation-induced lung damage (RILD) is a common consequence of lung cancer radiotherapy (RT). RILD is the likely cause of loss of breathing function in lung cancer survivors. RILD is traditionally described as a two-phased process according to time since RT: the acute phase (pneumonitis) occurring during the first 6 months following RT, and the permanent phase (pulmonary fibrosis) that stabilises 6 to 24 months after RT. However, in clinical practice the distinction between pneumonitis and fibrosis is often unclear. Since RILD is visible on CT imaging, its evolution can be objectively monitored and quantified. Our group has recently proposed a suite of biomarkers extracted from CT imaging to objectively quantify RILD 12-months after RT[1]. In this short paper we investigate the use of four representative imaging biomarkers to study evolution of radiological RILD up to 24 months after RT.

Type: Proceedings paper
Title: Objective imaging biomarkers to quantify the evolution of radiation-induced lung damage
Event: ICCR, 19th International Conference on the Use of Computers in Radiation Therapy
Location: Montreal (QC), Canada
Dates: 17th-21st June 2019
Open access status: An open access version is available from UCL Discovery
Publisher version: http://iccr-mcma.org/
Language: English
Additional information: This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Respiratory Medicine
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/10087589
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