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A proof‐of‐principle study comparing barrier function and cell morphology in face and body skin

Gorcea, M; Lane, ME; Moore, DJ; (2019) A proof‐of‐principle study comparing barrier function and cell morphology in face and body skin. International Journal of Cosmetic Science , 41 (6) pp. 613-616. 10.1111/ics.12568. Green open access

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Abstract

OBJECTIVE The purpose of this pilot in vivo study was to investigate corneocyte size and transepidermal water loss (TEWL) in facial cheek and volar forearm skin as a function of consecutive tape stripping. Changes in corneocyte size and transepidermal water loss (TEWL) were measured as a function of stratum corneum (SC) depth at both anatomical sites. To our knowledge, this is the first published quantitative comparison based on these parameters. This work complements our previously published studies on face skin barrier recovery at 24 h and 4 weeks post‐tape stripping [Gorcea et al., Skin Res. Technol., 19, 2013, e375‐e382; Gorcea et al., Int. J. Cosmet. Sci. 35, 2013, 250]. METHODS Transepidermal water loss in vivo measurements of forearm and facial skin sites were taken before tape stripping commenced (baseline) and after each tape was collected. Optical microscopy and image analysis techniques were employed to characterize corneocyte size as a function of skin depth (tape strip number) for both anatomical sites. RESULTS Transepidermal water loss increased significantly from baseline with sequential tape stripping at both anatomical skin sites. Volar forearm skin required approximately three times as many tapes to ‘damage’ the SC barrier (arbitrarily defined as twice baseline TEWL) compared to facial cheek skin demonstrating significant differences in barrier properties between cheeks and forearms (P < 0.05). Corneocyte size decreased significantly with depth for both sites (P < 0.001). Corneocytes from face skin were significantly smaller than corneocytes from volar forearm skin. CONCLUSION Statistically significant differences between facial and body skin stratum corneum cell morphology and transepidermal water loss were demonstrated and quantitatively measured as a function of tape stripping.

Type: Article
Title: A proof‐of‐principle study comparing barrier function and cell morphology in face and body skin
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/ics.12568
Publisher version: https://doi.org/10.1111/ics.12568
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Cheeks, forearms, SC barrier damage, TEWL, corneocyte size
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics
URI: https://discovery.ucl.ac.uk/id/eprint/10087414
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