UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Vesicular dysfunction and the pathogenesis of Parkinson’s disease: clues from genetic studies

Ebanks, K; Lewis, P; Bandopadhyay, R; (2020) Vesicular dysfunction and the pathogenesis of Parkinson’s disease: clues from genetic studies. Fontiers in Neuroscience , 13 , Article 1381. 10.3389/fnins.2019.01381. Green open access

[thumbnail of Bandopadhyay_fnins-13-01381.pdf]
Preview
Text
Bandopadhyay_fnins-13-01381.pdf - Published version

Download (779kB) | Preview

Abstract

Parkinson’s disease (PD) is a common age-related neurodegenerative disorder with disabling motor symptoms and no available disease modifying treatment. The majority of the PD cases are of unknown etiology, with both genetics and environment playing important roles. Over the past 25 years, however, genetic analysis of patients with familial history of Parkinson’s and, latterly, genome wide association studies (GWAS) have provided significant advances in our understanding of the causes of the disease. These genetic insights have uncovered pathways that are affected in both genetic and sporadic forms of PD. These pathways involve oxidative stress, abnormal protein homeostasis, mitochondrial dysfunction, and lysosomal defects. In addition, newly identified PD genes and GWAS nominated genes point toward synaptic changes involving vesicles. This review will highlight the genes that contribute PD risk relating to intracellular vesicle trafficking and their functional consequences. There is still much to investigate on this newly identified and converging pathway of vesicular dynamics and PD, which will aid in better understanding and suggest novel therapeutic strategies for PD patients.

Type: Article
Title: Vesicular dysfunction and the pathogenesis of Parkinson’s disease: clues from genetic studies
Open access status: An open access version is available from UCL Discovery
DOI: 10.3389/fnins.2019.01381
Publisher version: https://doi.org/10.3389/fnins.2019.01381
Language: English
Additional information: © 2020 Ebanks, Lewis and Bandopadhyay. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/10087390
Downloads since deposit
21Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item